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Opioid potencies
#BasicPharmacology
| Opioid Drug | Potency (Compared to Morphine) | Clinical Significance |
|---|---|---|
| Fentanyl | 50-100 times stronger | Highly potent opioid used for severe pain management, often used in anesthesia and chronic pain management. Requires careful dosing due to its high potency. |
| Carfentanil | 10,000 times stronger | Extremely potent opioid primarily used in veterinary medicine for large animals. Not intended for human use due to its high potency and potential for overdose. |
| Hydromorphone | 5-7 times stronger | Potent opioid used for moderate to severe pain relief. Commonly used in post-operative pain management and cancer-related pain. |
| Oxycodone | 1.5-2 times stronger | Moderately potent opioid used for moderate to severe pain management. Often prescribed for acute and chronic pain conditions. |
| Morphine | Standard potency | Widely used opioid for moderate to severe pain management. Considered the gold standard for comparison of other opioids. |
| Codeine | 0.1 times weaker | Mild to moderate opioid used for mild pain relief and cough suppression. Often combined with other medications. |
| Tramadol | 0.1 times weaker | Weak opioid used for mild to moderate pain relief. Also has additional mechanisms of action, making it useful for neuropathic pain. |
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Answers
2023 September 10
Axon Advocate
| Opioid Drug | Potency (Compared to Morphine) | Clinical Significance |
|---|---|---|
| Fentanyl | 50-100 times stronger | Highly potent opioid used for severe pain management, often used in anesthesia and chronic pain management. Requires careful dosing due to its high potency. |
| Carfentanil | 10,000 times stronger | Extremely potent opioid primarily used in veterinary medicine for large animals. Not intended for human use due to its high potency and potential for overdose. |
| Hydromorphone | 5-7 times stronger | Potent opioid used for moderate to severe pain relief. Commonly used in post-operative pain management and cancer-related pain. |
| Oxycodone | 1.5-2 times stronger | Moderately potent opioid used for moderate to severe pain management. Often prescribed for acute and chronic pain conditions. |
| Morphine | Standard potency | Widely used opioid for moderate to severe pain management. Considered the gold standard for comparison of other opioids. |
| Codeine | 0.1 times weaker | Mild to moderate opioid used for mild pain relief and cough suppression. Often combined with other medications. |
| Tramadol | 0.1 times weaker | Weak opioid used for mild to moderate pain relief. Also has additional mechanisms of action, making it useful for neuropathic pain. |
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2023 September 11
| Opioid | Clinical Significance |
|---|---|
| Meperidine (Demerol) | High risk of serotonin syndrome |
| Tramadol | Moderate risk of serotonin syndrome |
| Tapentadol | Moderate risk of serotonin syndrome |
| Methadone | Low risk of serotonin syndrome |
| Fentanyl | Low risk of serotonin syndrome |
| Morphine | Low risk of serotonin syndrome |
| Oxycodone | Low risk of serotonin syndrome |
| Hydrocodone | Low risk of serotonin syndrome |
Clinical Significance:
- Meperidine (Demerol): Meperidine has a high risk of precipitating serotonin syndrome due to its potential to inhibit serotonin reuptake and interact with other medications that increase serotonin levels.
- Tramadol and Tapentadol: These opioids have a moderate risk of serotonin syndrome as they also possess serotonin reuptake inhibition properties.
- Methadone, Fentanyl, Morphine, Oxycodone, and Hydrocodone: These opioids have a lower risk of serotonin syndrome compared to Meperidine, Tramadol, and Tapentadol.
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